Pure Encapsulations Adenosyl/Hydroxy B12 Liquid, 1 fl. oz.

Great product, prevents OVERMETHYLATION for those who are taking B12 supplement. Start slow, you don't need much, always check with a doctor first.

Excellent Vitamin B12! Right under the tongue with a Folinic lozenge for those with MTFHR mutation. Helps a lot with energy and nerves. No side effects for me. The liquid makes it absorb quickly and no stomach upset . Yes it’s pricey but worth the money .

This a great product. Great taste and easy to use.

I don’t usually write reviews but it really helped me to read others’ experiences. There isn’t much information online about adverse reactions or processing from methylcobalamin or cobalamin b12 supplements, which are most of the b12 supplements out there. My experience consisted of having low b12 and needing to supplement but all the supplements would cause lethargy starting about 2-3 hours after I took the supplement which would lead to shoulder/neck then head tension or a migraine. Higher doses would increase the effect and I had nausea a few times. And these would be from very high quality supplements. I even tried food based lower dose (250% DV) ones and still it had that effect to some, maybe a lesser degree. Dessicated liver seems fine but doesn’t raise the levels enough. It has felt like 5 years of a catch 22 of low b12 and feeling low energy so taking a supplement which makes me feel worse, but still needing b12. So anyways, I don’t know if I have a gene mutation or not. I haven’t been taking this form of b12 for very long but the difference was noticeable on day 1. Each serving size has around 41,000% of b12 and the bottle says to take 1-3 servings a day (1mL or one dropperful). I measured that each dropperful has around 20 drops, so if I take 5 drops I’m getting around 10,000%. Literally that’s all I have needed 1x a day, it’s pretty crazy. I stopped drinking coffee over a year ago but this supplement feels comparable to drinking coffee. Lots of energy and productivity and more of a clear head. I think if I took a whole serving size it would be too much energy!! I’m just so happy to feel like I have made a breakthrough with energy and b12.

Definitely on a health optimization journey. Postmenopausal. May my energy rest in peace. Have been taking quality methylated multi vitamin that included B6 for quite a while. Still had persistent lack of energy/fatigue. Bought this, and OMG! Life changing! I happen to have the MTHFR gene mutation (fascinating rabbit hole) and this type of B12 is amazing. Good steady energy, not at all like caffeine. Focus improvement, and just a sense of hey there’s hope it’s OK. Take one or two times a day. Amazing. Functional medicine doctor even supported the science behind it. Super light pleasant easy taste (not that that matters-could taste like old shoes & it would still be worth it.

As pictured, came quickly

I have homozygous mthfr c677t & ironically Methylated B12 normally gives me major anxiety and jittery feelings and headaches . Figured out I’m definitely over methylating. This form is much better for me. I’m taking an extremely low dose. Since it’s liquid it’s easy to customize my dose down to just a few drops vs a whole dropper. My low b12 and symptoms of it are improving quickly despite the small (tolerable) dose I’m taking. The only side effect was a slight headache the first couple days. So for someone very sensitive like me, this is a great option. Update 7/28/2024: in just as little as 6 weeks of doing these drops (micro dosing basically) my b12 went from low 300s to 670. I stopped supplementing at that point because I noticed that after I’d take it, I’d feel weepy and anxious rather than energetic and focused. I assume just my sensitive body telling me that I didn’t need anymore. This is how you know what’s optimal. I have had several rounds of blood work done since to keep a check on it and my numbers are holding! My low b12 symptoms are gone, and my health & anxiety has improved so much that I’m driving again and not feeling so withdrawn. Really great book suggestions to those considering b12 sups: Dirty genes by Ben lynch and Could it be B12 second edition (I forget the author name.

I know that I’m sensitive to lots of things, so I may be the only one to have this experience, but I started with two drops a day just to see if I could tolerate it and was fine. I worked my way up to 15 drops and the obsessive, racing thoughts were scary. I now only take about four drops a day. Honestly, I don’t know if it’s working or not since I have other deficiencies. I’ve only been taking it for about 18 days, so I’ll give it some more time.