---
product_id: 45862984
title: "Adapalene Gel 0.1% Acne Treatment, 45 gram, 180-day supply, 1.6 Ounce (Pack of 2)"
brand: "differin"
price: "€ 110.83"
currency: EUR
in_stock: true
reviews_count: 3
category: "Differin"
url: https://www.desertcart.sk/products/45862984-adapalene-gel-0-1-acne-treatment-45-gram-180-day
store_origin: SK
region: Slovakia
---

# 180-day supply (2 tubes) Up to 87% acne reduction in 12 weeks 0.1% Rx-strength adapalene Adapalene Gel 0.1% Acne Treatment, 45 gram, 180-day supply, 1.6 Ounce (Pack of 2)

**Brand:** differin
**Price:** € 110.83
**Availability:** ✅ In Stock

## Summary

> ⚡ Clear skin isn’t a dream—it's a 180-day commitment to confidence!

## Quick Answers

- **What is this?** Adapalene Gel 0.1% Acne Treatment, 45 gram, 180-day supply, 1.6 Ounce (Pack of 2) by differin
- **How much does it cost?** € 110.83 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.sk](https://www.desertcart.sk/products/45862984-adapalene-gel-0-1-acne-treatment-45-gram-180-day)

## Best For

- differin enthusiasts

## Why This Product

- Trusted differin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Patience Pays Off:** Designed for consistent use—embrace the initial purging phase for lasting, visible results.
- • **Deep Pore Penetration:** Targets acne at its root by regulating skin cell turnover and reducing inflammation.
- • **Long-Lasting Value Pack:** Two 1.6 oz tubes provide a 6-month supply, maximizing your skincare investment.
- • **Restores Natural Skin Texture:** Smooths and evens skin tone while preventing new breakouts from forming.
- • **Clinically Proven Acne Fighter:** Reduces acne by up to 87% in just 12 weeks with powerful retinoid action.

## Overview

Differin Adapalene Gel 0.1% is a dermatologist-recommended, prescription-strength retinoid acne treatment that penetrates deep into pores to clear and prevent pimples, blackheads, and clogged pores. Clinically proven to reduce acne by up to 87% in 12 weeks, this 45-gram dual-pack offers a 6-month supply, delivering long-term skin texture improvement and inflammation control. Ideal for millennials seeking effective, science-backed skincare that transforms their complexion with patience and persistence.

## Description

Differin Gel contains a Rx-strength acne-fighting retinoid. It clears breakouts where they start (deep in the pores), prevents acne before it begins, and as a result, restores skin’s texture and tone.

Review: Brave the storm, stick with it and you will be rewarded! - Hi, chronic adult acne sufferer here. Here I am, one whole year later. If you are brave enough to STICK with this thing for at LEAST 2 months, you won’t be disappointed. I will of course start off by describing my personal experience. My first 2 weeks were rough, but I was fully prepared for the struggle, after reading all about the initial "purging" stage. And still I almost wanted to quit 7 days in because of the irritation and peeling. I would wake up in the middle of the night sometimes because my skin feels like it's burning and ants are crawling all over it. Throughout the day, a light breeze that sends little strands of baby hairs tickling my skin is enough to inspire the urge to simply claw the skin off my face. I don't mean to scare anybody away haha but I want you to be FULLY prepared. Everybody is different, and you might be lucky enough that the irritation is on the milder side. But you will for SURE experience some kind of sensitivity, it is unavoidable and PART OF THE MECHANISM of action. The irritation MEANS the adapalene is doing its work! Think of it as skin boot camp! So many people use it for a few days, panic and quit right off the gate. I’ve heard one beauty guru on Youtube refer to his experience as “like getting a chemical burn that I never want to experience again”. Don’t be discouraged! Have no fear! Be brave! Moisturizer sandwich for the first 2 months! Moisturizer (bottom bread) - Differin (meat) - moisturizer (top bread). Apply moisturizer after showering when your skin is damp (whenever you shower during the day), then apply Differin in the evening or at bedtime, wait 15-20 mins for it to absorb, then apply moisturizer on top of the Differin. A light lotion is enough for me, I didn't need any hardcore Eucerin or even the recommended Differin moisturizer pairings. Just use what you normally do in your existing routine, and basically do extra layers on top to help ease the dreaded initial irritation. After about 3-4 weeks of diligent use, your skin will start to feel tight and bouncy, almost like baby skin, as if the old skin layer has shed itself to make way for a brand new layer of skin. To me, it’s like a cycle that will repeat itself when you make Differin a part of your routine (like brushing your teeth). Here is what is sort of looks like: Occasional breakouts and skin feeling a bit flaky/oily/weird & crummy --> Differin will work its magic --> breakouts will shrink and heal almost overnight --> old pigmentation/scars will fade and baby skin achieved for a while --> repeat cycle Another downside that may dissuade you: the price. It IS expensive but I am still working on my 1st tube almost one year later! It is a BIG tube and with this deal you get TWO TUBES. This will be more than enough to cover you for at LEAST 6 months, as long as you are using the correct amount (if you are running out before 6 months you are using way too much and NOT reaping any extra benefits). The instructions say once daily thin layer all over… but after about 4 months my skin had improved so much that I was no longer abiding by this regimen. As your skin improves you will find that you no longer need to be so stringent. Now I only use it sparingly and almost sporadically, often skipping a few nights in a row, always a very thin layer, almost like a spot-treatment concentrated more on the few active breakouts and pigmentation scars. The swelling goes down overnight, and the scars fade over time. Short of going on oral isotretinoin (which I am way too scared to ever try), birth control pills that might make some people’s acne even worse, aldosterone-blocking drugs and other much scarier medications with way riskier side effects, plus other hosts of expensive dermatologist treatments, adapalene (the active medicinal ingredient in Differin) alone is a sweet little miracle. All it takes is a lot of PATIENCE and PERSEVERANCE, but trust the science! Adapalene will deliver. Differin is NOT an overnight cure. It is not really a “cure”. And it will NOT work at all if you jump in using it as spot-treatment only (like benzoyl peroxide or salicylic acid). But it is the MOST effective thing you will find over-the-counter without a prescription. My skin is not crystal clear, I still get the familiar hormonal chin/jawline pimple beard, and the occasional acute stress monster breakouts, but it is now a 1/10 - 2/10 case of adult acne (with much-improved oil control and texture) compared to the 5/10 - 7/10 horrendous suffering I used to have to endure. TLDR: READ THE INSTRUCTIONS ON THE BOX. BE PREPARED. BE PATIENT. DO NOT GIVE UP!!!
Review: Definitely solves acne, great value - I was at my wits' end struggling with acne still at age 45. My skin type is combination/oily. I tried everything, expensive skin care routines, facials and treatments. For me, most of these actually seemed to irritate/make my breakouts worse. I had used Differin in my 20's when it was only available by prescription so I was delighted to see it avail without one so anyone struggling with acne can now easily get it. All I can say is - it REALLY works!!! A little goes a long way so these tubes last awhile - it is well worth the money even if shipping to Canada. You have to give it some time to get the results as the directions say (6-12 weeks) but it is worth it so you must stick with it even if you don't see immediate results. I'd describe my adult acne as moderate. For me it was very drying (and part of this is normal during the retinization phase). So after washing my face, I applied moisturizer and allowed that to dry for at least 5 min, and then applied a thin layer of Differin. You don't smear on a thick layer. I'm using it every other night instead of every night and it has smoothened my skin and completely cleared it. For more severe acne probably best to use daily as directed. There's some great tips for using this product from a Dr. Dray on YouTube.

## Features

- Clear and prevent acne with an Rx-strength retinoid
- Fights the main causes of acne by regulating skin cell turnover and reducing inflammation deep in the skin to clear and prevent pimples, blackheads and clogged pores
- Differin Gel can reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories)
- Effectively treats acne to restore your skin’s natural tone and texture
- The retinoid in Differin heals current acne and stops new acne from forming

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B073QS6JLF |
| Best Sellers Rank | #63,642 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #151 in Facial Cleansing Gels |
| Customer Reviews | 4.7 4.7 out of 5 stars (1,408) |
| Is Discontinued By Manufacturer  | No |
| Item model number  | 302994910458 |
| Manufacturer  | Galderma Laboratories, Inc |
| Product Dimensions  | 6.38 x 7.88 x 7.44 inches; 3.2 ounces |

## Images

![Adapalene Gel 0.1% Acne Treatment, 45 gram, 180-day supply, 1.6 Ounce (Pack of 2) - Image 1](https://m.media-amazon.com/images/I/718AvSqlGlL.jpg)

## Questions & Answers

**Q: Does this product help oily skin?**
A: It can for some. It varies from person to person. It helped with my whole skin in general to include lightening my blemishes and oily skin. I am very tan so not sure how it fairs with other skin types. Adapalene is a 3rd generation retinol. For retinol beginners, your skin may go thru a period of 'retinizing' which basically means it's getting use to the product. This can occur for a few weeks and you may experiences with redness, dryness, and peeling. I personally dealt with this and was okay with it cause i wanted to commit to the product entirely for the first month. I started seeing results 2-3 months thereafter and use this religiously in my skincare. Hope this info was helpful.

**Q: Will this remove any acne indents or acne divots from skin ?**
A: My son has been using this for about a year. It will not remove acne scars or indents. It is best for mild to moderate acne. It must be used everyday to get the best benefit. It is drying nd face will turn slightly pink for first couple wks or so but will resolve.

**Q: I am 75 years old and no longer have acne but heard helpful for wrinkles,possibly dark circles and bags under eyes-anyone use it for that purpose?**
A: I am in my 40s and occasionally have mild adult acne. I use this for skin health - not acne care. I have not noticed any change in acne, and I do not believe it does anything at all for dark circles, but I do feel that my skin looks healthier in general.

**Q: How long dose it take to restok and ship my goods?**
A: It depent on where you live. It took only 2 weeks to ship ro iceland and that is amazing from that company I dit buy it from. Often it take much longer then that

## Customer Reviews

### ⭐⭐⭐⭐⭐ Brave the storm, stick with it and you will be rewarded!
*by E***A on March 24, 2022*

Hi, chronic adult acne sufferer here. Here I am, one whole year later. If you are brave enough to STICK with this thing for at LEAST 2 months, you won’t be disappointed. I will of course start off by describing my personal experience. My first 2 weeks were rough, but I was fully prepared for the struggle, after reading all about the initial "purging" stage. And still I almost wanted to quit 7 days in because of the irritation and peeling. I would wake up in the middle of the night sometimes because my skin feels like it's burning and ants are crawling all over it. Throughout the day, a light breeze that sends little strands of baby hairs tickling my skin is enough to inspire the urge to simply claw the skin off my face. I don't mean to scare anybody away haha but I want you to be FULLY prepared. Everybody is different, and you might be lucky enough that the irritation is on the milder side. But you will for SURE experience some kind of sensitivity, it is unavoidable and PART OF THE MECHANISM of action. The irritation MEANS the adapalene is doing its work! Think of it as skin boot camp! So many people use it for a few days, panic and quit right off the gate. I’ve heard one beauty guru on Youtube refer to his experience as “like getting a chemical burn that I never want to experience again”. Don’t be discouraged! Have no fear! Be brave! Moisturizer sandwich for the first 2 months! Moisturizer (bottom bread) - Differin (meat) - moisturizer (top bread). Apply moisturizer after showering when your skin is damp (whenever you shower during the day), then apply Differin in the evening or at bedtime, wait 15-20 mins for it to absorb, then apply moisturizer on top of the Differin. A light lotion is enough for me, I didn't need any hardcore Eucerin or even the recommended Differin moisturizer pairings. Just use what you normally do in your existing routine, and basically do extra layers on top to help ease the dreaded initial irritation. After about 3-4 weeks of diligent use, your skin will start to feel tight and bouncy, almost like baby skin, as if the old skin layer has shed itself to make way for a brand new layer of skin. To me, it’s like a cycle that will repeat itself when you make Differin a part of your routine (like brushing your teeth). Here is what is sort of looks like: Occasional breakouts and skin feeling a bit flaky/oily/weird & crummy --> Differin will work its magic --> breakouts will shrink and heal almost overnight --> old pigmentation/scars will fade and baby skin achieved for a while --> repeat cycle Another downside that may dissuade you: the price. It IS expensive but I am still working on my 1st tube almost one year later! It is a BIG tube and with this deal you get TWO TUBES. This will be more than enough to cover you for at LEAST 6 months, as long as you are using the correct amount (if you are running out before 6 months you are using way too much and NOT reaping any extra benefits). The instructions say once daily thin layer all over… but after about 4 months my skin had improved so much that I was no longer abiding by this regimen. As your skin improves you will find that you no longer need to be so stringent. Now I only use it sparingly and almost sporadically, often skipping a few nights in a row, always a very thin layer, almost like a spot-treatment concentrated more on the few active breakouts and pigmentation scars. The swelling goes down overnight, and the scars fade over time. Short of going on oral isotretinoin (which I am way too scared to ever try), birth control pills that might make some people’s acne even worse, aldosterone-blocking drugs and other much scarier medications with way riskier side effects, plus other hosts of expensive dermatologist treatments, adapalene (the active medicinal ingredient in Differin) alone is a sweet little miracle. All it takes is a lot of PATIENCE and PERSEVERANCE, but trust the science! Adapalene will deliver. Differin is NOT an overnight cure. It is not really a “cure”. And it will NOT work at all if you jump in using it as spot-treatment only (like benzoyl peroxide or salicylic acid). But it is the MOST effective thing you will find over-the-counter without a prescription. My skin is not crystal clear, I still get the familiar hormonal chin/jawline pimple beard, and the occasional acute stress monster breakouts, but it is now a 1/10 - 2/10 case of adult acne (with much-improved oil control and texture) compared to the 5/10 - 7/10 horrendous suffering I used to have to endure. TLDR: READ THE INSTRUCTIONS ON THE BOX. BE PREPARED. BE PATIENT. DO NOT GIVE UP!!!

### ⭐⭐⭐⭐⭐ Definitely solves acne, great value
*by R***B on September 20, 2021*

I was at my wits' end struggling with acne still at age 45. My skin type is combination/oily. I tried everything, expensive skin care routines, facials and treatments. For me, most of these actually seemed to irritate/make my breakouts worse. I had used Differin in my 20's when it was only available by prescription so I was delighted to see it avail without one so anyone struggling with acne can now easily get it. All I can say is - it REALLY works!!! A little goes a long way so these tubes last awhile - it is well worth the money even if shipping to Canada. You have to give it some time to get the results as the directions say (6-12 weeks) but it is worth it so you must stick with it even if you don't see immediate results. I'd describe my adult acne as moderate. For me it was very drying (and part of this is normal during the retinization phase). So after washing my face, I applied moisturizer and allowed that to dry for at least 5 min, and then applied a thin layer of Differin. You don't smear on a thick layer. I'm using it every other night instead of every night and it has smoothened my skin and completely cleared it. For more severe acne probably best to use daily as directed. There's some great tips for using this product from a Dr. Dray on YouTube.

### ⭐⭐⭐⭐⭐ From cystic acne to truly beautiful skin (and now without a prescription?!)
*by T***S on December 9, 2017*

I am an acne veteran. 25 years of painful experience. I have tried various combinations of erythromycin, benzamycin, benzoyl peroxide (2.5%, 5%, 10%), salicylic acid (2.5% and peels of 10% to 30%), finacea, ziana, mandelic acid, glycolic acid etc. I have tried pills, lotions, creams, serums, and peels. I have tried a host of dietary restrictions, exercise, sleeping sitting up (to avoid irritation from the pillow). I could literally write a book. Until differin gel. So, I have been on this for the past 7 years. On and off, according to whether or not I was pregnant. It is the only thing that has given me truly *beautiful* skin, as opposed to clear skin. Acne sufferers know the difference. It is one thing to have skin that is technically acne-free, but is covered in scars and hyperpigmentation. That is what benzoyl peroxide mixed with glycolic acid (I followed the acne.org regimen) in the morning and finacea at night got me. But beautiful skin? Nope. I still had to use tons of makeup. Differin gel took away my post-inflammatory hyperpigmentation, roughness, large pores, and resurfaced my pockmarks. And it happened quickly. I got there by using the 0.3%, which is still prescription-only. But I maintain now with this over-the-counter concentration. I still use a 30% glycolic acid peel every month and spot treat the occasion pimple with benzoyl peroxide. But wow, differin gel made a huge difference. I go make-up free pretty much all the time now. Good luck!

## Frequently Bought Together

- Differin Adapalene Gel 0.1% Acne Treatment, 45 gram, 180-day supply, 1.6 Ounce (Pack of 2)
- PanOxyl Acne Foaming Wash Benzoyl Peroxide 10% Maximum Strength Antimicrobial, 5.5 Oz

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*Product available on Desertcart Slovakia*
*Store origin: SK*
*Last updated: 2026-01-26*