---
product_id: 635096637
title: "Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested"
brand: "science"
price: "€ 98.93"
currency: EUR
in_stock: true
reviews_count: 8
category: "Renue By Science"
url: https://www.desertcart.sk/products/635096637-renue-by-science-trigonelline-high-strength-trigonelline-trg-methylated-niacin
store_origin: SK
region: Slovakia
---

# 250mg Trigonelline per capsule Third-party tested & Non-GMO Supports NAD+ synthesis & DNA repair Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested

**Brand:** science
**Price:** € 98.93
**Availability:** ✅ In Stock

## Summary

> ⚡ Unlock your body's youthful energy with science-backed Trigonelline!

## Quick Answers

- **What is this?** Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested by science
- **How much does it cost?** € 98.93 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.sk](https://www.desertcart.sk/products/635096637-renue-by-science-trigonelline-high-strength-trigonelline-trg-methylated-niacin)

## Best For

- science enthusiasts

## Why This Product

- Trusted science brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Cellular Energy Amplifier:** Boost muscle NAD+ production for enhanced vitality and recovery.
- • **Molecular Longevity Shield:** Promotes DNA repair and protects against tissue aging at the cellular level.
- • **Clean & Transparent Quality:** Non-GMO, USA-made, and rigorously third-party tested for purity and potency.
- • **Flush-Free Niacin Alternative:** Enjoy niacin benefits without the uncomfortable flushing effect.
- • **Systemic Brain & Body Support:** Stable through digestion, crosses blood-brain barrier, fueling heart, brain, and muscles.

## Overview

Renue By Science Trigonelline delivers a potent 250mg dose of methylated niacin that uniquely supports NAD+ synthesis, DNA repair, and tissue longevity. Made in the USA with Non-GMO ingredients and third-party tested, this supplement offers a clean, flush-free alternative to traditional niacin, promoting cellular energy, cognitive function, and anti-aging benefits for a modern, health-conscious lifestyle.

## Description

Buy Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested on desertcart.com ✓ FREE SHIPPING on qualified orders

Review: A Single Ingredient Supplement Providing Focused Benefits from a Quality Company. - As an adherent of a natural approach to health and wellness, and to that end include supplements that aid in a variety of modalities, including physical and mental performance, nutrition and when called for, healing, what I look for first and foremost, is that the company selling the product is transparent. In addition, that they are also the developer of the product; in other words, I avoid third-party distributors for what I assume are obvious reasons. It’s my opinion that it’s the quality of the company that determines the quality of a supplement, bearing in mind a product that’s going to be consumed. Renue by Science checks all of those boxes I look for in a supplier of supplements and natural remedies. They provide transparency in the form of test reports, their products are third-party tested, they have an evolved website that includes contact information for customer service and their business is located in the USA. They are the developers of the products they sell and, in this case, specialize in longevity products, the modality of the product being offered here. Their American staff includes a Ph.D. in Biochemical and Molecular Nutrition and a doctor whose specialty is anti-aging and regenerative medicine. This defines the research behind the product. In addition, the company’s mission statement is in alignment with the benefits being asserted for their Trigonelline Methylated Niacin supplement. As quoted from their website: “Our goal is to provide you with the highest quality, most extensive range of bioavailable longevity products at the absolute lowest price. Renue By Science has been driving longevity research forward since its foundation, and continues to innovate with novel molecules and the most effective delivery systems. Each batch of every product is rigorously tested by third-party labs and backed by clinical research to provide quality and effectiveness that isn’t available anywhere else.” Trigonelline, a major alkaloid component of fenugreek, is an herb used in traditional Chinese herbology and medicine. Besides the performance benefits stated by the seller, there is research available on the web concluding that Trigonelline may have a number of pharmacological uses that may aid in the amelioration of some specific, and what is becoming more common, conditions. As a suggestion, it may be worthwhile for the reader to do some due diligence of their own. In fact, it’s for those potential benefits that I ordered Trigonelline for my wife. Also, of course, because what women wouldn’t have high hopes for a supplement that “Protects Against Tissue Aging.” Their Trigonelline supplement isn’t the first I’ve ordered from Renue By Science, that’s because I consider them a trusted source of quality supplements.
Review: Renue By Science Trigonelline - This is my first experience with the supplement Trigonellen-Methylated Niacin. So far, I like it. I've had no negative side effects, the single capsule per day is easy to take and I feel it gives me more energy and focus, although that is hard to measure. I'm especially interested in supplements that are pure, clean and third-party tested. This one checks off all those boxes for me. It also purports to offer anti-aging properties, which I also find of great interest. I'll continue with my daily dosage, as I like this supplement a lot. The bottle is a 90 day supply. I think this is a good value for what you get though, TBH, I did not do any price comparisons with similar products. It seems affordable to me.

## Features

- Muscle NAD+ Synthesis: By promoting NAD+ synthesis in muscle through the Preiss-Handler pathway, Trigonelline enhances cellular energy and repair, supporting overall health and longevity. Supports muscle NAD+ production, unlike NMN or NR. It provides the precursors needed to generate NAD+ that becomes depleted through cellular metabolism and aging.
- DNA Repair and Cellular Integrity: Encouraging cellular repair and maintaining DNA integrity, Trigonelline protects against cellular damage and promotes health at the molecular level. Additionally donates methyl groups which promote healthy gene expression.
- Protects Against Tissue Aging: Supplies much-needed NAD+ precursors to tissues like the heart, brain, and muscles. NAD+ declines fastest in tissues that experience the most oxidative damage and physiological use, so using Trigonelline to refuel these tissues protects youthful heart, brain, and muscle function, preserving strength and cognition.
- Broad Longevity Support: Unlike other NAD+ precursors, Trigonelline is stable through digestion and enters circulation for systemic tissue delivery. Once in circulation it can support healthy sugar and lipid metabolism and does not cause the flushing effect that many experience with niacin.
- Naturally Occurring NAD+ Support: Trigonelline is found in numerous plant foods including coffee and fenugreek. This highly bioavailable and stable molecule can cross the blood-brain barrier and is quickly metabolized into NAD+, measurably impacting circulating and intracellular levels of this critical molecule.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B0D74QBVQG |
| Best Sellers Rank | #52,270 in Health & Household ( See Top 100 in Health & Household ) #97 in Vitamin B3 (Niacin) Supplements |
| Customer Reviews | 4.0 4.0 out of 5 stars (33) |
| Date First Available  | June 14, 2024 |
| Manufacturer  | Renue By Science |
| Package Dimensions  | 4.45 x 2.13 x 2.13 inches; 3.21 ounces |

## Product Details

- **Age Range (Description):** Adult
- **Brand:** Renue By Science
- **Dosage Form:** Capsule
- **Flavor:** Unflavored
- **Item Form:** Capsule
- **Number of Items:** 1
- **Package Information:** Bottle
- **Product Benefits:** Muscle Growth
- **UPC:** 850055685277
- **Unit Count:** 90.00 Count

## Images

![Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested - Image 1](https://m.media-amazon.com/images/I/61dOX0P+paL.jpg)
![Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested - Image 2](https://m.media-amazon.com/images/I/61hYNH8ZMbL.jpg)
![Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested - Image 3](https://m.media-amazon.com/images/I/61qnMljTakL.jpg)
![Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party Tested - Image 4](https://m.media-amazon.com/images/I/61tVMmYYneL.jpg)

## Customer Reviews

### ⭐⭐⭐⭐⭐ A Single Ingredient Supplement Providing Focused Benefits from a Quality Company.
*by D***. on September 12, 2024*

As an adherent of a natural approach to health and wellness, and to that end include supplements that aid in a variety of modalities, including physical and mental performance, nutrition and when called for, healing, what I look for first and foremost, is that the company selling the product is transparent. In addition, that they are also the developer of the product; in other words, I avoid third-party distributors for what I assume are obvious reasons. It’s my opinion that it’s the quality of the company that determines the quality of a supplement, bearing in mind a product that’s going to be consumed. Renue by Science checks all of those boxes I look for in a supplier of supplements and natural remedies. They provide transparency in the form of test reports, their products are third-party tested, they have an evolved website that includes contact information for customer service and their business is located in the USA. They are the developers of the products they sell and, in this case, specialize in longevity products, the modality of the product being offered here. Their American staff includes a Ph.D. in Biochemical and Molecular Nutrition and a doctor whose specialty is anti-aging and regenerative medicine. This defines the research behind the product. In addition, the company’s mission statement is in alignment with the benefits being asserted for their Trigonelline Methylated Niacin supplement. As quoted from their website: “Our goal is to provide you with the highest quality, most extensive range of bioavailable longevity products at the absolute lowest price. Renue By Science has been driving longevity research forward since its foundation, and continues to innovate with novel molecules and the most effective delivery systems. Each batch of every product is rigorously tested by third-party labs and backed by clinical research to provide quality and effectiveness that isn’t available anywhere else.” Trigonelline, a major alkaloid component of fenugreek, is an herb used in traditional Chinese herbology and medicine. Besides the performance benefits stated by the seller, there is research available on the web concluding that Trigonelline may have a number of pharmacological uses that may aid in the amelioration of some specific, and what is becoming more common, conditions. As a suggestion, it may be worthwhile for the reader to do some due diligence of their own. In fact, it’s for those potential benefits that I ordered Trigonelline for my wife. Also, of course, because what women wouldn’t have high hopes for a supplement that “Protects Against Tissue Aging.” Their Trigonelline supplement isn’t the first I’ve ordered from Renue By Science, that’s because I consider them a trusted source of quality supplements.

### ⭐⭐⭐⭐⭐ Renue By Science Trigonelline
*by C***C on March 12, 2025*

This is my first experience with the supplement Trigonellen-Methylated Niacin. So far, I like it. I've had no negative side effects, the single capsule per day is easy to take and I feel it gives me more energy and focus, although that is hard to measure. I'm especially interested in supplements that are pure, clean and third-party tested. This one checks off all those boxes for me. It also purports to offer anti-aging properties, which I also find of great interest. I'll continue with my daily dosage, as I like this supplement a lot. The bottle is a 90 day supply. I think this is a good value for what you get though, TBH, I did not do any price comparisons with similar products. It seems affordable to me.

### ⭐⭐⭐⭐⭐ Trustworthy and full transparency!
*by M***C on October 1, 2024*

This is a review for Renue By Science Trigonelline TRG Methylated Niacin 250 mg, 90 Capsules. Trigonelline is a form of Niacin. It is a natural molecule found in coffee, the herb fenugreek, and also in the human body. It may help to improve muscle health and function, particularly important for the aging population. This brand RENUE by SCIENCE and it's founder have a fascinating back story (found on thier website) that has led to a successful company focused on anti-aging supplements. I was not too familiar with all these forms of niacin, Nr, Nad, Nadh, NmN. Renue's website gave me a thorough education in plain English about all these different nutrients and on Trigonelline and why it may be of help if you are looking for anti-aging support. Renue is an American company. They have included their contact information online. Their ingredients are non-GMO, tested in ISO-Certified and cGMP certified labs. I have been taking this product now for 2 weeks and have not noticed any digestive distress. I have noticed a bit of mental and physical energy. I expect it will take a couple of months to notice the full benefits of this supplement ( as in most supplements) The suggested dosage is 1 a day and there are 90 days worth of capsules in this bottle. This is a trustworthy company, and I recommend this Trigonelline.

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*Product available on Desertcart Slovakia*
*Store origin: SK*
*Last updated: 2026-01-31*