When adding new fish or changing water do I have to use the entire 5ml/10gallon rule ?

I would do it if it were me. Most fish come from pet stores that are severly overstocked and under maintained so they are already stressed when you bring them home. Add to that the fact that they are being moved for the umpteeth time and they can use all the help they can get. I will say that I do use half doses when I move my fish from one tank to another only because they tanks are well maintained and the water parameters are pretty much the same so the fish are less stressed. Other people may have different opinions but this is my process and it works for me. I have four tanks. I have a 125, 90, 55 and a 40. I have been in the hobby for over 15 years. I also keep two aquatic turtles as well. Hope this helps.

any views on this product versus API's stresscoat?

Different products, API is a water conditioner, stressguard is an antiseptic for open wounds, cuts. I used StressGuard occasionally and API on water changes.

Do you have to remove purigen from your filter

No. Generally Seachem products are safe to use with other Seachem products. Normal filters, nor purigen filters have to be removed when using Stress Guard. It's perfectly safe.

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🛡️ Protect your aquatic friends like a pro—because stress is so last season!

FLEXIBLE DOSING - Use 2.5-5ml per 10 gallons daily, with safe doubling for faster results.
SAFE COMPATIBLE - pH neutral formula won’t alter aquarium conditions or interfere with medications (except copper-based).
NON CLOGGING FORMULA - Unlike competitors, it won’t coat resins or clog filtration systems.
ULTIMATE STRESS REDUCTION - Calms fish and neutralizes ammonia toxicity during transport and handling.
ADVANCED HEALING TECHNOLOGY - Protein-active colloids bind to wounds, acting as a liquid bandage to speed recovery.

Seachem Stress Guard is a 500ml premium liquid treatment designed to reduce fish stress and ammonia toxicity during handling or transport. Its unique protein-active colloids promote rapid wound healing by binding to exposed proteins, acting as a liquid bandage while preventing infections. pH neutral and compatible with most medications, it protects your aquarium’s delicate balance without clogging filters.

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Brand	Seachem
Liquid Volume	500 Millilitres
Item Weight	522 g
Item Form	Liquid
Manufacturer	SEACHEM LABORATORIES, SEACHEM LABORATORIES
UPC	000116052306
Global Trade Identification Number	00000116052306
Manufacturer	SEACHEM LABORATORIES
Country of Origin	USA
Item model number	523
Product Dimensions	16.76 x 6.1 x 5.84 cm; 521.63 g
ASIN	B001F0KX06

Seachem Laboratories Stress Guard 500Ml

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