P-5-P (Pyridoxal 5-Phosphate) | 25 mg Active Vitamin B6 Supplement | 100 Vegetarian Capsules | Seeking Health

New research Oct 2017 study (The Vitamin B6 Paradox) on Researchgate showed that taking the pyridoxine form of b6 in larger doses actually leads to decreased vitamin b6 function and symptoms of deficiency. The inactive form pyridoxine competitively inhibits the active pyridoxal-5-phosphate form and both pyridoxal 5 phosphate dependent enzymes were inhibited by pyridoxine. So the more pyridoxine you take, the more it can work against you and even lead to deficiency B6 symptoms. It also mentions it was toxic even at lower doses killing cells, and Lareb reported that some found doses as low as 2mg/day caused the same neuropathy symptoms as higher doses. This product is Pyrodoxal-5-phosphate, the active form which doesnt have any of those issues, and so in my opinion seems to be the better way to supplement vitamin b6 and why I chose it and now avoid pyridoxine as much as I can. Vitamin B6 in the non active form also needs Magnesium, Zinc, and Vitamin B2 to convert to its active form. As many are low on magnesium, or are under stress which depletes both magnesium and zinc, it seems that many may not be converting Vitamin B6 as well. There are also genetic mutations MTHFR that some may have that can keep the conversion from occuring. Seeking Health is a high quality brand, and this B6 does not have many of the fillers others do. I would buy again anytime I need a standalone B6 supplement. I also use their Seeking Health B Minus which has 20mg P5P with the other B vitamins except B12 and also Folate, which can be added separate as needed. Has my review been of help to you? If so, would you consider hitting the "helpful" button below? I'd greatly appreciate it. Thank you!

My Doctor recommended these and I do feel better when I take them.

Absolutely solid P5P brand. Definitely helped manage my prolactin levels while on TRT. Would like to mention I did not go guns blazing with dosage. I took it very slow while seeing how my body reacts. Overall mood and sleep are the greatest things that improved! Would highly recommend giving this a shot if you’re in the same boat.

I always had toxic issues with B6. This active version of B6- P5P I take with no problem. With this supplement (which I take only 1 25mg pill every other day), I have vivid dreams which I remember pretty well, and I believe (and hope) that I'm getting a deeper, higher quality sleep as well. There are some interesting reports of reduction of anxiety, depression, and help with burning feet and a host of other possibilities with P5P especially if you have found standard B6 to be toxic to some degree. Try this P5P. Be your own doctor and decide how much to take, how often, and for how long. I am not one who believes more is always better. Give it a try and see if your dreams and sleep are positively affected. After 6 months: I've cut back to 2 25mg pills a week, and may cut back more or stop for a while at least as it seems my body has enough B6 (p5p) now. No rules in all this, I just notice I'm getting good sleep and dreams with less and less p5p. Learning as I go along ... Be cautious about taking too much....

After reading about the negative side effects I could tell I hit my saturation point after 4 days at 50mg per day. Even at 25mg in the morning daily my tongue tingles and pulses so I am now taking it every other day or less to avoid over saturation and nerve damage.