What is the difference of the 100 and the 250 mill

150 ml is exactly the difference. 250 ml is 150 ml more than the 100 ml. Over twice as much.

Is possible to use this item for removing blackhead ?

Probably not. This is usually used for eczema and psoriasis. For blackheads, I would suggest a product containing salycylic acid such as Neutrogena Rapid Clear Acne Eliminating Spot Gel.

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