Vetoquinol Zylkene Calming Support Supplement for Small Dogs and Cats, Helps Promote Relaxation and Reduce External Stress Factors, Daily Behavioral Support and Anxiety Relief for Dogs and Cats, 75mg

I have a 4-year-old Maine Coon with a sensory processing disorder. My big boy, Barnum, has trouble processing textures and noises. I have the only Maine Coon in America who HATES to be brushed no matter the brush or comb used. (We have 12.) Everyday noises — the doorbell, microwave alarm, TV volume — completely unhinge him and send him running for his life. Prozac helped to some degree, but it also flattened him emotionally and didn’t fully address the sensory overload. Since adding Zylkene alongside an reduced Prozac dose, the change has been remarkable. Barnum is calmer (no longer flinching when the duct work in the attic pops or the ice maker drops ice), more social, and genuinely enjoying life again. He seeks affection, engages in play, and even participates in brush sessions willingly (with freeze dried chicken incentives!). The difference is subtle but profound — his nervous system feels soothed, not sedated. I give him 1 capsule every morning. 2 made him sleep all day. Zylkene has balanced his sensory overload and allowed his personality and spirit to come back. He’s alert but regulated, playful but not anxious, and much more comfortable navigating the household and daily life. Any owner of a cat with anxiety or sensory issue should try Zylkene. Worth every penny!

We love these, they help calm our dog. Max has breathing difficulties and these help him relax and breath better

My experience comes from a cat shelter and, in recent years, working as a professional cat behavior consultant. It's hard to know with supplements if they really are effective, especially when they are used in conjunction with other behavior modification strategies. I can say that I used them with my cats for about a month as we were transitioning into our new home, and I thought they were helpful. I like that they have fewer potential side effects than prescription medication. Most cats don't mind the taste. For cats with more discerning taste, you can give the gel caps whole, on a lick mat in a pile of mixed-texture treats. The only drawback, from my perspective, is these supplements are pricey, which makes them less feasible for long-term use.

This is a NON-Drowsy supplement that truly does work! This calms my cat without making him sleepy so that I'm able to take him to the vet or give him needed medication. In addition, he is a hyper personality and sometimes is aggressive to our other cat & this supplement makes him less so. I like it that it doesn't change his personality or activity level but it does help him accept medication and vet visits.

I have a small terrier with allergies and anxiety. For her to be happy, I have to manage both. This product does a good job of relaxing her, though it is not the only thing I use. I do notice when I stop using it she is antsier, so I have chosen to continue the product. But the price continues to increase from expensive to untenable. I looked around for alternatives. The active ingredient is called Alpha-Casozepine, according to the label. So, in looking for products with this, it turns out that Lactium is a trademarked version of this. It was difficult to find a product with this alone. Ultimately, I found a Swanson Antistress human product that contained only this as an active ingredient. There are other products that have this ingredient along with other things that I didn't want. I'll see how this new product works once I receive it. Interestingly, Calmkeen, a product that markets itself as similar, has hydrolyzed milk protein as the active ingredient, but it does does not have the actual Alpha-Casozepine. I bought it to alternate with Zylkene, but it simply does not work as well for my dog. And the price, which is significantly cheaper than Zylkene, has continued to rise likely because Zylkene's has. Anyway, if money is no option, then Zylkene is an effective product. If you don't want to continue to pay chronic price increases, you may need to look for an alternative.

Update 2 months: This is absolutely necessary to keep the peace in my household. I have started to give her slightly more than 75mg, because it wasn’t working as well after a while but giving her 1 pill plus a little sprinkle from the second pill works great. She is just over the weight suggested for the 75mg. I tried to give it every other day but it just was not working as well as every day. We still smoosh it into a few pill pockets and make like a dough and then I pinch off treat size pieces and she loves it! She cries for it every morning and that is what she wants for breakfast lol. She’s now refusing wet food because this is what she wants. Update 7 days after initial review: I have been giving 1/2 of a 75mg capsule twice a day to my cat for 7 days straight now and she has not attacked my other cat in 7 days! We usually have stalking and attacking constantly so to go from constantly to none is very impressive! What I really like is that she still has her personality and does not seem drugged in any way. She just isn’t a psychopath stalker anymore 🤷🏻‍♀️. I plan on continuing the regimen and giving 1/2 to her twice a day. I started by sprinkling half a capsule on her wet food but she doesn’t eat all of it (she doesn’t mind the powder at all) so instead I have been buying pill pockets and I just knead it into the pill pocket like a dough and she eats it right up. This way she gets the full dose and I’m not wasting any. Initial review: My vet recommended that I try this before we put my cat on Prozac. I have two cats. My cats are not litter mates, they are both 6 years old and I adopted them one year apart. Pandora was the second cat I adopted and she has turned out to be a little psychopath. She constantly bullies and stalks and chases and attacks my other cat. It drives me insane and at times it’s extremely draining. I have tried very good quality lab tested CBD, and every kind of feliway spray and diffuser there is. Nothing works. I purchased this about 8 months ago and the first time I gave it to her she full on attacked my foot (not playing, it was very aggressive) and she has never done that before. So I have not given it to her again. Out of desperation, I am revisiting this option, after reading more about how to administer, I think she probably just needs more time to adjust. I sprinkled half of one capsule on top of about a tablespoon of wet food. She ate almost all of it right away. I purchased some pill pockets and I think I can smush the powder into them and feed it to her that way to ensure she gets as much of the product as possible without wasting any. She goes crazy for pill pockets! I’ll gladly update this review once we finish the bottle. Tonight was the first night we started it again and she walked around the house looking for something to get into for about 30 minutes (typical) and then laid down and went to sleep.

We have four cats and three feliway diffusers, but we also have a frisky boy cat who lately decided he likes to harass our older girl. The girl cat started picking out patches of fur and hiding at the top of the cat tree. Two days of treatment for them and the fur chewing stopped, the aggression has stopped, and they are both really getting back to normal. It's nice not to hear hissing! We plan to use the whole bottle and hopefully break the habits. We use churo treats and mix two capsules into one churo for each cat. Works great!

LuLu’s coat is smoother, softer, and her dandruff is abating. This is bcz she’s losing weight, becoming more flexible, and therefore is grooming more frequently. 🥳 She’s a good kitty but food obsessed, and quite aggressive toward Poppy at times. Altho Poppy starts fights that she can’t finish… Anyway, I believe I owe LuLu’s cooperation with her weight management plan to this supplement; Zylkene👇 She’s not food stressed, even with the diet food and reduced daily calories. Highly recommend. ⭐️⭐️⭐️⭐️+